Lady Mary Wortley Montagu played an important role in promoting the adoption of the first "vaccine" -- before the word "vaccine" was invented. This was inoculation for smallpox, using actual pus from smallpox pustules.
Inoculation was being practiced in several parts of the world well before western medicine took notice of it. Knowledge of it spread to western Europe and the Americas during the early 18th century.
The most influential source of knowledge came from the Ottoman Empire. The most famous conveyor of the knowledge was Lady Mary Wortley Montagu, whose husband was British ambassador to the Ottoman Sultan for several years in the 1710s.
Lady Mary learned about the practice from Greek peasant women. She had contracted smallpox as a child, and her face still bore scars from it. Smallpox was one of the greatest killers in human history. Survivors often ended up scarred like Mary, and some were blinded by the disease. The benefit of having survived was that one was henceforth immune from it. Lady Mary had her own children inoculated while in Istanbul (then Constantinople).
(Images: 1. Lady Mary and her son in "Turkish" dress. 2. Lady Mary with a black servant.)
After returning to Britain, Lady Mary encouraged physicians to experiment with the procedure in the 1720s. One of the most important experiments involved the inoculation of the children of Princess Caroline of Anspach, wife of the future George II.The princess was no doubt influenced by the death from smallpox of Queen Mary, wife of William III, in 1694 (Image: Queen Mary).
The success of these experiments, combined with news of similar successes in America promoted by Rev. Cotton Mather of Massachusetts and others, led to the practice becoming common in the British Empire by the mid-18th century. (Image: Cotton Mather)
The procedure was not without its dangers. About one percent of those inoculated died. In contrast, however, natural smallpox had fatality rates often exceeding 20 per cent. After 1800, inoculation with actual smallpox was gradually replaced by the less dangerous method of using "cowpox" matter to immunize against the disease. Smallpox and the First Vaccine
The romanticized image below shows Edward Jenner inoculating James Phipps with cowpox matter from pustules on the hand of Sarah Neames, a milkmaid. She is pictured here on the far right wrapping her hand. Milkmaids and others who worked with cows sometimes became infected with cowpox, a much less serious but related viral disease.Jenner's method gave us the words "vaccine" and "vaccination," derived from "vacca, the Latin for "cow." The spread of vaccination in the 19th and 20th centuries led to the global eradication of smallpox by 1979, the first and so far the only infectious disease to be eliminated by human action.
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